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Lower starting doses produce fewer noticeable early effects, while genetic variation in receptor sensitivity influences the speed of appetite signal modulation

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A five-year, randomized, double-blind, placebo-controlled trial in healthy Danish older people (ages at inclusion, 60-74 years) found that selenium supplementation (100-300 g/day) had little-to-no impact on circulating levels of antioxidant enzymes, including GPx (166)

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