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Deletion of the calcitonin/calcitonin gene-related peptide CT/CGRP gene in a mouse model leads to a higher bone mass, (22) a finding that is supported by a similar phenotype in mice in which the CT receptor is deleted (23) In both model systems, disruption of the CT signaling pathway leads to increased bone formation, a surprising finding that argues for a role of this peptide as an inhibitor of bone formation
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