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The potential benefits of combining GLP-1RAs with basal insulin are contemplated in the current position statement of both the American Diabetes Association (ADA) [1] and the American Association of Clinical Endocrinologists (AACE) [2]

It is unlikely, however, that these effects would contribute to the suppression of water intake observed following GLP-1R stimulation, as diuresis and increased sodium excretion would more likely generate compensatory increases in fluid and solute consumption

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