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Promote proliferation and differentiation of osteoblasts, accelerate bone formation Activate key signaling pathways in osteoblasts Wnt/ - catenin pathway: AOD 9604 upregulates Wnt3a expression, activates - catenin nuclear translocation, promotes osteoblast proliferation and differentiation, and enhances osteoblast quantity and activity

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Each has its own timing pattern: Constipation tends to worsen gradually over the first 48 to 72 hours after injection, then slowly improve as drug levels decrease

Extreme/rapid weight loss may result in nutritional deficiencies that lead to hair loss, anemia, weak bones or increased risk of infection

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