can glp 1 cause insulin resistance The Role of Glp-1 Receptor Agonists in with Concomitant Obesity Treatment in Polycystic Ovary Syndrome Schematic of action of GLP-1

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Simultaneously, AMPK suppresses the nuclear translocation of sterol regulatory element-binding protein 1c (SREBP1c), downregulating the expression of key lipogenic enzymes such as fatty acid synthase (FASN) and stearoyl-CoA desaturase 1 (SCD1), thereby inhibiting de novo triglyceride (TG) synthesis

These are preclinical research observations only

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This opinion is supported by a study showing activity-driven ATP production at axon terminals [57]