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DA-depleting agents and DA receptor antagonists effectively reduce abnormal movements in HD 3,4 , demonstrating the contribution of DA to motor dysfunction

As discussed above, one of the key microbial pathways affecting host behavior is via bacteria-produced metabolites

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AmirpourMMirshekarMASedaghatGMontazerifarFShourestaniSArabmoazzenSet al

Genetic factors affecting receptor expression or downstream signaling may limit effectiveness