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In these patients, benefits have variably included reduced fat mass, increased lean mass, increased bone density, improved lipid profile, reduced cardiovascular risk factors, and improved psychosocial well-being

In the 1 mg trial arm, liver fat fell 51% among participants with fatty liver, visceral fat fell 16%, triglycerides declined, and ketones rose as the liver used more fat. Modeled metabolic-health protocols place heavier, metabolically average profiles near 1 mg weekly

The cumulative excretion amounts of M0, M3, M4, and M5 in the urine, feces and bile are shown in Figure 6