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SURMOUNT-5 Investigators

Sulforaphane may diminish neuroinflammation (by reducing NF-B and TNF- , and increasing IL-10) (Santn-Mrquez et al., 2019), reduce beta-amyloid and tau production (Zhang et al., 2017), and blood brain barrier integrity (Santn-Mrquez et al., 2019)

In contrast, cystine decreased the number of Salmonella in both tissues (Figure 2B), pointing to a protective effect of cystine on Salmonella translocation to extra-intestinal organs

Xu S, Flanagan JL, Simmons PA, Vehige J, Willcox MD, Garrett Q

The FDA has approved these agents for type 2 diabetes management (not type 1 diabetes or diabetic ketoacidosis), with select formulations also approved for chronic weight management in adults with obesity or overweight with weight-related comorbidities