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For patients with type 2 diabetes, dose advancement is considered when hemoglobin A1c remains above target (typically 7% for most adults, though individualized based on patient factors) or when fasting and postprandial glucose levels exceed goals

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The GWAS was performed including covariates as described in equation 1 above, with the addition of five genetic principal components to account for fine-scale genetic ancestry, and indicator variables to account for variation in the genotyping platform

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