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Treatments that could address redox metabolism abnormalities include methylcobalamin with and without folinic acid in open-label studies and vitamin C and N -acetyl-l-cysteine in DBPC studies

Dose escalation schedules in GLP-1-based therapies are typically gradual precisely to allow the body to adapt and to minimise GI side effects a principle acknowledged in NICE guidance on approved agents (see NICE TA875)

Plus, proper hydration keeps the skin elasticity high, so there tends to be lower chances of sagging