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Mechanistically, ox-LDL induces lipid peroxidation by inhibiting the SREBP-1/SCD1/FADS2-mediated lipid biosynthesis pathway, leading to endothelial damage and ultimately inducing ferroptosis (46)

Identified localization for PKCs are also perikarya or cell bodies of the striatum (caudate-putamen), among other brain regions (Saito et al., 1988), synaptic vesicles axon terminals (Figure 1, and along with the cAMP-PKA pathways, both are two important components of memory and learning systems (Lorenzetti et al., 2008)

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