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Hypersensitivity reactions may manifest as urticaria, angioedema, bronchospasm, or anaphylaxis, and any previous allergic reaction to tirzepatide or related GLP-1 receptor agonists should be considered an absolute contraindication

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In muscle, lipid content was positively related to the mRNA levels of LPL and ACCb and the activities of LPL and 6PGD and negatively related to the expression of ATGL (Table 5)

Accurate measurement requires imaging such as CT, MRI, DEXA, or validated ultrasound, or clinical proxies such as changes in waist circumference, fasting insulin, HOMA-IR, or liver enzymes