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Ranolazine works by inhibiting the late phase of the inward sodium current (late INa) in cardiac cells, which helps reduce intracellular calcium overload

Factors that may influence perioperative management include: Medication characteristics : Daily GLP-1 medications (liraglutide, oral semaglutide) have shorter durations of action than weekly formulations (injectable semaglutide, dulaglutide, exenatide extended-release) [3] Risk factors : Higher doses, recent dose increases, active gastrointestinal symptoms, or known gastroparesis may increase risk [1] [3] Procedure type : More complex surgeries or those requiring general anaesthesia may warrant different approaches than minor procedures Individual patient factors : BMI, presence of diabetes, and other medical conditions Some anaesthetists may recommend temporarily pausing GLP-1 therapy before certain procedures, particularly for patients with additional risk factors

Hankemeier, et al

Common side effects include swelling, redness, bruising, and soreness in the treated area

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