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Similar longer-term studies as part of the STEP Trail published in Nature Medicine showed up to 2 years of Semaglutide treatment induced similar weight loss of ~16kg, showing a tapering off in weight loss, where no further weight loss is achieved [13]

The STEP trials (semaglutide) and SURMOUNT trials (tirzepatide) enrolled thousands of participants and demonstrated that GLP-1 therapy produces meaningful, sustained weight loss across diverse populations, with acceptable safety profiles when used under medical supervision