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NAD+, or nicotinamide adenine dinucleotide, is a vital coenzyme present in every living cell, playing a significant role in energy metabolism and cellular repair

It secretes inflammatory cytokines like interleukin-6 and tumor necrosis factor-alpha

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Nevertheless, various stimuli such as chronic disease states, metabolic conditions (e.g., type 2 diabetes mellitus [T2DM], obesity, dyslipidemia), smoking, and disturbed blood flow can disrupt such a quiescent phenotype and lead to endothelial cell dysfunction (ECD) (Fig

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