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Un essai ouvert de mthylcobalamine intraveineuse ultra-haute dose a rapport quelle tait sre et potentiellement bnfique dans la neuropathie priphrique avec dgnrescence axonale chronique, [2] tandis que des revues systmatiques rapportent des effets modestes, plus marqus dans les protocoles combins, et notent que la qualit des essais est limite