Studies investigating ischemic kidney injury have shown that deletion of the alternative complement pathway attenuates injury from ischemia-reperfusion (97), as well as in C3a knockout mice, reduces the formation of NETs after ischemia, thereby protecting the kidney (96)
The PK parameters showed dose-proportionality, with a short terminal half-life of 2 hours, a clearance of 0.078 L/h/kg and a volume of distribution at steady-state of 0.22 L/kg
[DOI] [PubMed] [Google Scholar] Hashimoto T, Hashimoto K, Matsuzawa D, Shimizu E, Sekine Y, Inada T, Ozaki N, Iwata N, Harano M, Komiyama T, Yamada M, Sora I, Ujike H, Iyo M
Conclusion In summary, GLP-1 receptor agonists provide a hopeful strategy for reducing the impact of obstructive sleep apnea by promoting weight loss, but mechanical airway support like CPAP or oral appliances still holds the vital role for individuals in maintaining airway patency during sleep
Cabungcal JH, Steullet P, Morishita H, Kraftsik R, Cunod M, et al
