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The extrinsic pathway is initiated by death receptor-mediated or granzyme-dependent mechanisms [45]

60-70% of lost weight For such patients with a BMI criteria for bariatric surgery (BMI 35, or BMI 30 with other co-morbid conditions such as diabetes, sleep apnea, or hypertension), surgery offers long-lasting solutions with significantly greater effectiveness compared to years on medication

Early flares reflect crystal mobilisation and do not indicate treatment failure

Acknowledgements This work was supported by the National Institutes of Health (R01 GM056414, to S.H.G.)

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