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doi: 10.1152/ajpgi.1992.263.5.G617

Thus, it appears that different GLP-1R agonists activate arcuate POMC neurons through distinct ion channels, as previously discussed in the context of biased agonism among different melanocortin-4 receptor agonists [20]

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Patients with renal impairment may be at increased risk of hypoglycemia and may require more frequent NOVOLOG dose adjustment and more frequent blood glucose monitoring [see Warnings and Precautions (5.3) and Clinical Pharmacology (12.3)]