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The scope of the review is intentionally selective rather than exhaustive, focusing on peptidereceptor systems that demonstrate biological plausibility, mechanistic coherence, and unmet therapeutic potential, yet lack approved therapeutic analogs or advanced clinical programs

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Suppression of copper transporter ATP7B has been linked to alterations in intracellular copper trafficking as well as lipid metabolism and cell cycle machinery in an Atp7b-/- mouse model [5, 6]

A network meta-analysis published recently confirmed this pattern, finding that retatrutide demonstrated greater absolute weight reduction compared to tirzepatide (retatrutide: MD -16.34 kg vs tirzepatide: MD -11.82 kg)

In diabetics, where is the floor for weight and A1c