Cancer Sci 111(2):667678 Satoh H, Moriguchi T, Taguchi K, Takai J, Maher JM, Suzuki T, Winnard PT Jr, Raman V, Ebina M, Nukiwa T, Yamamoto M (2010) Nrf2-deficiency creates a responsive microenvironment for metastasis to the lung
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Since GSH oxidation involves hydrogen peroxide reduction, any issue in GSH metabolism is apt to cause an overabundance of oxygen radicals
| 2023 | Int J Mol Sci 2NAD metabolism: Implications in aging and longevity | Yaku et al
If this signified reduced cellular energy generation, it would contradict the notion that the other enzymatic changes were favorable