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Acknowledgements This work is funded by the Department of Defense Ovarian Cancer Research Program pilot award (W81XWH-22-1-0318) and the NIGMS-funded Pharmacology Training Program (T32 144303)

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At the level of gene transcription, the fact that three different proteins can be synthesized from gpx4, due to the presence of multiple transcriptional start sites, yielding the mitochondrial (m-), nuclear (n-), and cytosolic (c-) GPx4 forms, makes the issue of gene regulation extremely complex 54

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