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Under physiological conditions, moderate levels of autophagy effectively mitigate both endogenous and exogenous inflammatory responses by inhibiting NLRP3 inflammasome activation [111]

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Obesity is a major cause of morbidity and mortality in children and adolescents with this syndrome via deterioration of the POMC-MC4R anorectic pathways [7, 8]

119,166 Interestingly, the prevalence of this variant varies among different populations, with higher frequencies observed in Asian populations