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GLP-1 peptide analysis is among the most demanding workflows in modern pharmaceutical separation science, because semaglutide, tirzepatide, and related receptor agonists generate dense impurity profiles whose components differ from the parent molecule by only a single oxidation, deletion, or stereochemical inversion

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However, the authors of the review noted that these data were based on 2 RCTs only and that further studies are needed (11)

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