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Reports have linked the drug to blood clots in the legs, including DVT and other thromboembolic events

These high-energy particles can directly break chemical bonds and form ROS, leading to extensive cellular damage [54]

In addition, superoxide and superoxide-derived oxidants, shown by ethidium fluorescence, increased after the last MDMA injection, an effect that was prevented by sildenafil pretreatment

The combination group experienced faster and greater repigmentation overall, with stronger differences reported on the face and upper extremities