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Impact of cigarette smoking on the gastrointestinal tract inflammation: opposing effects in Crohns disease and ulcerative colitis

Kalantaridou SN, Davis SR, Calis KA

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doi: 10.1002/rmb2.12006

A 12-week study in humans where participants were given 500mg of berberine 3 times a day resulted in: an average weight loss of 5lb (2.3kg) a 23% reduction in triglycerides (a type of blood fat) a 12.2% reduction in cholesterol However, animal studies show that berberine has a very low bioavailability of less than 1% (how much of it is absorbed in your bloodstream), which may affect its effectiveness