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[57] AD is associated with an accumulation of DNA damage (double-strand breaks) in vulnerable neuronal and glial cell populations from early stages onward, [58] and DNA double-strand breaks are increased in the hippocampus of AD brains compared to non-AD control brains

Immune cells responsible for inflammation express the vitamin D receptor, and vitamin D successfully suppresses chronic inflammation in multiple settings, while vitamin D deficiency is associated with a pro-inflammatory state (Mohd 2022