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[1] The more immediate practical safety concern is the quality and sourcing of the compound itself

report holding United States patents (US 7,927,880 B2 19 April 2011 and US 8,192,997 B2 5 June 2012) and European patents (EP2250500B, 24 April 2013) for the methods and kit for the measurement of serum catalytic iron for early detection of acute coronary syndrome and prediction of adverse cardiac events

It is chemically modified to extend its half-life and duration of action

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Moreover, both hypoxia (via HIF-1) and TGF signaling can independently stimulate the VEGF and CXCR4 expression to drive breast cancer bone metastases (107)