Serious but rare side effects: Acute pancreatitis (severe abdominal pain) Gallstones Allergic reactions (rash, swelling, difficulty breathing) Monitor for signs of dehydration due to gastrointestinal side effects
Fish oil supplements providing 2 to 3 grams of combined EPA and DHA daily are commonly recommended
Most patients notice reduced appetite within the first 24 weeks
Semaglutide drives the caloric deficit and fat loss
When to Contact Your Prescriber While most side effects resolve on their own once the body adjusts, the below call for medical attention - Vomiting that persists beyond 48 hours Severe abdominal pain, especially pain that goes all the way to your back (potential sign of pancreatitis) Unable to keep fluids down for more than 24 hours Yellowing of skin or eyes (potential sign of liver issues) Racing heart, palpitations, or chest discomfort Sudden vision changes in one eye (MHRA NAION warning, February 2026) Any signs of an allergic reaction like swelling, rash, difficulty breathing The idea here is not to scare you, but to keep you informed enough so you know what to do once something goes unplanned