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In this study we selected a low dose of GE2, based on prior research in rats (60) and the original study using this conjugate (59), after guidance from the Novo Nordisk team (BF, JD, BY)

GIP and GLP-1 may exert long-term effects on -cell survival and proliferation, potentially delaying the development of and even reversing T2DM

The FDA's boxed warning for semaglutide explicitly states that the drug has been shown to cause thyroid C-cell tumors in rodent studies and is contraindicated in patients with a personal or family history of medullary thyroid carcinoma (MTC) or in patients with Multiple Endocrine Neoplasia syndrome type 2 (MEN 2)

Kara Rood, MD Advisory Board - Postpartum Hemorrhage OB/GYN Asst

MASH and ALD share several similarities, including excess intake of nutrients or ethanol, and the pathological features of hepatic steatosis, inflammation and fibrosis 5,6