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Core Methodology: Sample Collection and Preparation: RBC samples were collected from Diversity Outbred (J:DO) mice, both fresh and after seven days of refrigerated storage

Overexpression of B7-H3 increased phosphorylation of Jak2 and Stat3, which resulted in increased expression of MMP-9

4,18 Data suggest that dulaglutide and liraglutide may be associated with higher rates of nausea, vomiting, and constipation compared with semaglutide, whereas pharmacovigilance analyses indicate that semaglutide carries the greatest signal strength for these AEs

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2 In the REIMAGINE 3 trial, the most commonly reported AEs were GI-related, occurring in 51/90 (57%) participants in the CagriSema 2.4 mg/2.4 mg group, 42/93 (45%) participants in the CagriSema 1 mg/1 mg group, and 21/91 (23%) participants in the placebo group