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HernandezAFGreenJBJanmohamedSD'Agostino RBSrGrangerCBJonesNPet alAlbiglutide and cardiovascular outcomes in patients with type 2 diabetes and cardiovascular disease (harmony outcomes): a double-blind, randomised placebo-controlled trial

Ruthvik Sunil Kumar

Benefit: May enhance cognitive function, improve memory, support brain health, stabilize mood, and reduce symptoms of depression

However, LCN2, a downstream target of NF-B, exhibits paradoxical effects on ferroptosisboth promoting and inhibiting it in different contextsadding complexity to the role of NF-B in this process

Combination therapy is typically considered when monotherapy or dual therapy with other agents (such as metformin) fails to achieve adequate glycaemic targets, or when patients require additional cardiovascular or renal protection