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Levels of vitamin B12 were normalized

It is a well-tolerated compound with a clean safety profile and a genuinely interesting mechanism that, so far, has produced results in humans that fall short of what animal models predicted

Providing support for a causal link between a negative energy state and increased Parasutterella abundance, a rat model of obesity, which showed similar Parasutterella relative abundances in animals maintained on HFD and those maintained on normal chow but exhibited a treatment-induced increase in Parasutterella relative abundance, displayed a negative correlation between Parasutterella and body weight 82

The compound was never approved as a pharmaceutical treatment for obesity because the Phase 2 clinical trial results, while showing safety and modest efficacy, did not meet the threshold for drug registration

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