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Answer and interpretation This is probably valproic acid induced hyperammonia encephalopathy (VHE) VHE has been reported secondary to acute VPA overdose and in chronic normal therapeutic dosing, presenting as an acute and profound decreased level of consciousness, with or without increased seizure activity this is usually in association with an increased serum ammonia level (Mock and Schwetschenau, 2008) Patients at higher risk for VHE include those with liver impairment, on multiple anticonvulsants, or have other causes of increased ammonia production

Front endocrinology

It can assist by increasing the bodys ability to burn stored fat for energy, especially when combined with proper diet and exercise

doi:10.3748/wjg.v23.i48.8465 38

It reflects the pharmacokinetic reality of semaglutide, which has a half-life of approximately one week