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fisetin in particular blocks the degradation of IB (the inhibitor of NF-B), which prevents the nuclear translocation of NF-B and the downstream inflammatory cascade (25)

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This leptin-induced reduction in GABA action at POMC neurons is a disinhibition and is, in part, the mechanism by which leptin decreases feeding behaviors

The combination of these two measures can reveal a link between cochlear neuropathy and central neural hyperactivity, providing characteristic evidence that cochlear synaptopathyseen as a reduction in wave-I amplitudeis followed by compensatory central gain, reflected in the relatively stable amplitude of wave V 11,45