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Intervertebral Disc Degeneration GLP-1 protects nucleus pulposus cells (NPCs) ( the primary cell type driving disc integrity) by inhibiting AP-1driven catabolic gene transcription (specifically BATF/JUN heterodimers that drive MMP13 and ADAMTS5), curtailing NF-B via SIRT1 upregulation, and differentially modulating STAT3 (suppressing pathological senescence in NPCs while promoting M2 macrophage polarization)

Composite probiotics alleviate type 2 diabetes by regulating intestinal microbiota and inducing GLP-1 secretion in db/db mice

Recent studies indicate that this powerful amino acid may halt or disrupt cancer cell formation and bolster the health of tissues surrounding cancers