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Br J Pharmacol 178:13361352 Dreser A, Vollrath JT, Sechi A et al (2017) The ALS-linked E102Q mutation in sigma receptor-1 leads to ER stress-mediated defects in protein homeostasis and dysregulation of RNA-binding proteins

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Chronic elevation of these free radicals will deplete GSH/GSSG redox/antioxidant capacity, allowing unopposed free-radical generation and a self-perpetuating cycle, leading to chronic oxidative stress and damage

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Storage & Handling Store refrigerated at 28C Protect from excessive heat and sunlight Use sterile handling practices Avoid repeated vial contamination Important Disclaimer For laboratory and research purposes only

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