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Pattern recognition receptors (PRRs), including Toll-like receptors (TLRs) and NOD-like receptors (NLRs), sense microbial components and damage-associated molecular patterns (DAMPs), triggering activation of signaling cascades such as NF-B, MAPK, and inflammasomes (e.g., NLRP3), which further amplify the inflammatory response [40]

Techniques such as mindfulness, adequate sleep, and relaxation exercises support overall digestive health

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Moreover, traditional drug delivery systems (DDSs)primarily oral tablets and intravenous injectionsfail to address localized MSU crystal deposition or provide sustained drug release, leading to recurrent flares and chronic joint damage (Mohamad et al., 2025

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