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Most common side effects were gastrointestinal, with 24.5% of participants in the phase 2 obesity trial discontinuing efinopegdutide 10 mg due to AE however when the same dose was used with gradual escalation at the MASLD trial (starting dose 2.4 mg for 4 weeks, then 5 mg for 4 weeks and then 10 mg), only 5.6% of participants discontinued the medication due to AE

Brain iron homeostasis and mental disorders

Discontinuation due to adverse events was 9.8% (9 mg) and 13.5% (12 mg), versus 4.8% on placebo -- higher than the rates reported in TRIUMPH-2 (3.8% / 11.6% / 7.7%), in a considerably sicker population

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Zhong J, Chen H, Liu Q, Zhou S, Liu Z, Xiao Y