When gastric emptying slows, oral medications may take longer to reach the small intestine, where most absorption occurs
Therefore, further exploration is needed on how to improve the phenomenon of weight rebound after stopping semaglutide intervention, other pathways affected by semaglutide, and whether improvement in obesity can be achieved through direct intervention with key metabolites/key bacterial genera
Thirdly, these medications provide a non-invasive alternative to revisional surgery, which carries additional operative risks and may not be suitable for all patients
Neuropharmacology (2014) 76(PART A):5767
At this point, the ICER for switching from a weekly injection to a daily pill would exceed $100,000 per QALY gained