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Eur J Pediatr 150 , 425428

By targeting melatonin synthesis and circadian gene expression, Epitalon could act as a molecular metronome, realigning internal timekeeping mechanisms that tend to falter with age

It is worth mentioning that the genetically proxied effect of GLP-1RAs exhibited a causal effect on liver fibrosis in MASLD (OR: 3.70 10 4 , 95%CI: 5.29 10 6 0.03, P = 2.66 10 4 ) despite negative results in liver fibrosis (Supplementary Table 5)

Their review, however, identified no studies stratifying the potential role of GLP-1 RAs across overlapping dermatologic and rheumatologic conditions, suggesting that future multidisciplinary trials should incorporate these factors

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