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The two primary incretin hormones glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic peptide (GIP) are released from the small intestine after eating

11.1 What GLP-1 Therapy Does Not Do Current evidence does not support the claim that GLP-1 receptor agonists: Cause universal micronutrient depletion Directly impair intestinal absorption Mimic bariatric malabsorption Require blanket supplementation Intestinal anatomy remains intact

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Gastric emptying is particularly problematic during endoscopy because it increases the risk of aspiration by producing retained gastric contents, which interfere with visualization during esophagogastroduodenoscopy (EGD)