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The study has found that SFRP4 is involved in ISO-induced cardiomyocyte mitochondrial damage, and using an SFRP4 inhibitor can alleviate mitochondrial dysfunction in the myocardium and HL-1 cells (195)

974,975 However, other studies have shown that NAC does not reduce the risk of contrast-induced acute kidney injury or improve clinical symptoms in patients with diabetes (NCT00736866)