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Importantly, several phytochemicals demonstrate metabolic benefits by enhancing GLP-1/GIP signaling through DPP-IV inhibition, providing a biologically plausible route for synergistic neuroprotection in PD ( Therefore, future clinical strategies should investigate whether phytomolecules, either independently or in combination with GLP-1/incretin mimetics, can provide enhanced neuroprotection and improve both motor and non-motor outcomes in PD

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In the REDEFINE 1 trial, coadministration of cagrilintide 2.4 mg (a long-acting amylin analog) and semaglutide 2.4 mg (CagriSema) resulted in a 20.4% mean Weight loss at 68 weeks in adults with overweight or obesity

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