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Proposed mechanisms of Tesamorelin: Activates GHRH receptors Increases endogenous GH release Elevates IGF-1 production Promotes lipolysis Reduces visceral adipose tissue Why Tesamorelin is unique: Unlike most weight-loss therapies, Tesamorelin appears particularly effective at reducing visceral fat the deep abdominal fat surrounding internal organs that is strongly associated with insulin resistance, cardiovascular disease, and metabolic syndrome

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Some clinical discussions suggest that GHRH analogs like Sermorelin may produce GH release patterns more similar to natural pulsatile secretion since they work through the endogenous pathway

1Thymosin 4 and cardiac protection: implication in inflammation and fibrosisPubMed / Annals of the New York Academy of Sciences 2012 2Thymosin beta 4: a multi-functional regenerative peptidePubMed / Expert Opinion on Biological Therapy 2012

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