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Similarly, while the previous study 19 showed higher levels of protein C, which is a prothrombinase complex inhibitor, in splenectomized patients as compared to healthy volunteers and non splenctomized patients, our study showed increase activation of the prothrombinase complex as shown by the increased levels of prothrombin fragment 1 + 2 in the splenectomized patients

To minimize this, it is often helpful to start with a smaller dose and ensure you are staying well-hydrated

J Antibiot

However, pharmacokinetic studies indicate that oral GSH supplementation has variable absorption rates and limited bioavailability

Acknowledgements Not applicable Funding This research was supported by the Ministry of Science, Education and Sports, Republic of Croatia (grant number 108-1083570-3635)