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How long does it take to see weight loss results on semaglutide? Most patients notice appetite suppression within the first week at starting dose, but meaningful weight reduction defined as 5% or more of body weight typically takes 812 weeks at therapeutic dose

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This effect seems to be very important for the normalization of postprandial glucose (PPG) elevations, and potentially even more important than the insulinotropic effects of GLP-1 for maintaining PPG homeostasis [19]

That is why it is typically given as a daily injection, often at night to mirror natural growth-hormone rhythm