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Finally, the actions of the elevated IGF-1 levels are increased because of the drop in IGFBP-1 (Fig

Important context before you continue: Tesamorelin and Ipamorelin are often discussed together, but they serve different roles depending on the goal

Sermorelin's FDA Journey: Approved, Discontinued, and Compounded Sermorelin acetate (Geref) was FDA-approved in 1997 for pediatric GHD 1 and in 1990 for diagnostic use.26 The manufacturer discontinued Geref in 2008 due to "manufacturing difficulties," not safety or efficacy concerns.12 In 2013, the FDA confirmed it wasn't withdrawn for safety/effectiveness, allowing for potential generic approvals.12 Currently, Sermorelin is primarily available as a compounded medication 3, which is permitted but not individually FDA-approved like mass-produced drugs.22 5.2

More from this series: see the full Peptides for Muscle Growth pillar guide for the complete framework, peptide-family breakdown, and decision tree.

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