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It has been modified from the natural GLP-1 sequence to resist degradation by the enzyme DPP-4, which is why it lasts much longer in the body than natural GLP-1

Additional contraceptive methods are recommended during this period

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Published in JAMA, the Journal of the American Medical Association, the study found that the use of Glucagon-like peptide agonists increases the risk of bowel obstruction and gastroparesis