[14] [15] In general, the bulk of the evidence does not indicate that thiazide diuretics are teratogenic in the 1st trimester, although, many experts limit their use to the 2nd and 3rd trimesters

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Br J Nutr (2005) 93(6):84551
The decision was made on the same day the US Food and Drug Administration (FDA) approved a version of tirzepatide called Zepbound for weight management
Avoid mega-doses of single nutrients without a known deficiency